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At the end of the chain, pigment synthesis is stimulated, with a documented preference for eumelanin, the brown-black pigment

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Frequency varies by study design

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d , Quantification of reaction products of coupled reactions using clarified E.coli cell lysates expressing Ph AN9 and At LDOX with 200 M 3,4 cis -leucocyanidin ( 6 )

Severity typically correlates with dose and individual sensitivity rather than the compound itself being inherently dangerous