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It naturally binds with the precursor of eumelanin, the pigment responsible for dark complexions, and creates pheomelanin, a lighter pigment

In the STEP clinical trial program, 2.4 mg was the target maintenance dose that produced an average 14.9% total body weight reduction at 68 weeks (Wilding et al., New England Journal of Medicine 2021)

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The structural components of the skin barrier include keratinocytes, internal structural proteins, and specific skin lipids (Yosipovitch et al., 2019)