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PMID 31285847

Consult a healthcare professional prior to use especially if you are pregnant or breastfeeding or if you have a fever, vomiting, bloody diarrhoea or severe abdominal pain

Once inside the mitochondrial matrix, Cu 2+ is reduced to the more reactive Cu + by ferredoxin-1 (FDX1) ( + binds to the lipoyl-lysine residues of DLAT, promoting its oligomerization and functional disruption, which impairs the pyruvate dehydrogenase complex and compromises TCA cycle activity, leading to proteotoxic stress and mitochondrial dysfunction ( Cuproptosis is further modulated by GSH and p53

There are many risk factors for BPH

It further demonstrates the feasibility of developing actionable and highly precise functional interventions by integrating genomic and biochemical data

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