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TRIUMPH-4: Knee Osteoarthritis The Most Overlooked Trial TRIUMPH-4 is the retatrutide trial that most guides overlook but for patients with obesity-related joint pain, it may be the most clinically relevant
The trial also evaluated a treatment policy analysis that included all participants regardless of adherence, which showed 13.6% average weight loss still significantly higher than placebo
2022, Cell Metabolism)
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Similar results were found in a clinical study in patients with T2DM, where administration of liraglutide, but not metformin, increased the relative abundance of Akkermansia , which is often associated with the improvement of gastric mucosa and also becomes severely depleted in diabetic patients [115]
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