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Tirzepatide may be favored for those with complex diabetes or insulin resistance, while semaglutide is also effective and has a longer safety record in diabetes management

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Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats

Real-world data show around 50% of people who take weight management drugs discontinue within 1 year, although some people reinitiate therapy at a later date (Rodriguez et al, 2025)