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The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been determined to interfere with assays for cholesterol, uric acid" where "NAC interference may lead to falsely low results

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Second, they reduce oxidative stress

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Silencing of RRM1 in HT-1080 Control cells decreased the corresponding protein levels and led to compensatory up-regulation of RRM2, indicating that our silencing reagent worked as expected (Fig 5A)

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