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In the prevalent sequential progression model, cancer cells first spread to regional LNs and then disseminate to distant organs via the lymphatic system (149)

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[6] Children in some regions of developing countries are at particular risk due to increased requirements during growth coupled with diets low in animal-sourced foods

Biochem Soc Trans 34:330333

Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011