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Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions

Liraglutide exerts antioxidant and anti-inflammatory effects on endothelial cells by inhibiting protein kinase C-, NADPH oxidase and NF-B signaling, while upregulating protective antioxidant enzymes (132)

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Therefore, -cell failure is considered to play a major role in the pathogenesis of the disease