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Signs and symptoms of autism include: Speech delay or regression Delay in normal childhood milestones, such as walking Sensitivity to sound or to certain noises No reciprocal gestures, such as responding to games A child 6 months of age or older that does not smile or has stopped smiling Repetitive behaviors are common Often times the child doesnt want to be touched Loud noises can be extremely disturbing to the child In addition to these symptoms, systemic inflammation, gastrointestinal immune-related problems, and changes in the gut microbiota are characteristic for people with autism (1)

Corresponding target agents have been applied for patients ( Table 3 )

In their separate Phase 2 trials, retatrutide monotherapy showed larger weight loss (~24.2% at 48 weeks, 12 mg) than standalone cagrilintide (~10.8% at 26 weeks, 4.5 mg), and indirect network meta-analyses rank retatrutide highly

Valid only through 3/23/26

173 StroherE.MillarA

2013;8:e73316