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79 In addition to their anti-diabetic effects, SGLT-2is play a role in cardio-nephroprotection due to RAAS activation from their diuretic and sympathoinhibition effects

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As shortages abate, FDAs time-boxed enforcement discretion for compounded semaglutide/tirzepatide ended in spring 2025, pushing patients and payers back to branded pathways and putting a premium on compliant, high-throughput operations