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In sleep studies, an increase in deep NREM phases and an improvement in overall sleep quality have been observed

If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended (10, 13)

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Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature