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4.8
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Description

2021: A systematic review of 11 RCTs in 203 adults found some improvements in VOmax and peak power, but no studies showed benefit for moderate-intensity exercise [3][61]

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Interestingly, another mechanism was proposed as an alternative way to stabilize NRF2 through the interaction between the autophagy adaptor protein p62/sequestosome-1 (p62/SQSTM1) and KEAP1, which leads to the sequestration of KEAP1 in the autophagy-deficient cells and enables NRF2 accumulation [20]

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