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FIGURE 2 3.2 Inflammatory pathway activation via mtROS and mtDNA leakage 3.2.1 mtROS and the NLRP3 inflammasome mtROS is a potent activator of the NLRP3 inflammasome, a multiprotein platform composed of NLRP3, ASC, and caspase-1 (Wang et al., 2024)

Antioxidants (Basel), 13 (6), 706

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Plasma Oxidized Glutathione: Showed no significant changes in either group

6.5 Other regulatory mechanisms The interplay between ferroptosis and epigenetic regulation has garnered increasing attention due to their shared associations with oxidative stress and dysregulated iron metabolism