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Central nervous system (CNS) development Although the action mechanisms of IGF-I in neurons have not been fully elucidated, it has been shown that IGF-I stimulates the autophosphorylation of IGF-IR[53] in a different manner to insulin[54]

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It emphasizes that long-term adherence and lifestyle integration matter most, with regular follow-up visits, continued physical activity, balanced nutrition counseling, and openly reporting side effects to the care team