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The more precise framing: PCOS is a systemic metabolic-endocrine dysfunction characterized by four overlapping dysfunctions that reinforce one another in a self-sustaining cascade

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PMC 5986001

This sustained start may lead to different patterns of downstream signaling and gene expression compared to the pulsatile start that occurs with native IGF-1

E11.40 covers unspecified diabetic neuropathy in Type 2 diabetes, while E11.42 specifically codes diabetic polyneuropathy, the most common neuropathy subtype

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