There was a notable link between GLP-1 treatments and hair thinning: a 37 percent higher risk compared to SGLT-2 inhibitors, and a 68 percent higher risk compared to DPP-4 inhibitors
Some patients have shared what they describe as unexpected behavioral shifts, such as naturally drinking less alcohol or feeling less drawn to certain habits
The trials did not show dramatic muscle loss in well-nourished participants, but this was not the primary outcome measured, and individual dietary behaviour varies significantly outside controlled trial conditions
Once-weekly formulations like semaglutide reach steady-state concentrations after approximately 45 weeks, while dulaglutide typically reaches steady state in 24 weeks
Methodological standards for body composition: an expert-endorsed guide for research and clinical applications
Tirzepatide (Mounjaro, Zepbound) is a related but distinct medication that acts as a dual GIP/GLP-1 receptor agonist