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It can also be used for poisoning by organophosphorus, amino, or nitro aromatic compounds
Mechanistic experiments using the PI3K inhibitor wortmannin demonstrated that PI3K/AKT signaling is required for the anti-inflammatory and anti-apoptotic effects, identifying the brain AngIV/PI3K/AKT axis as the proximate mechanism in this model
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But the reviewers graded the evidence as very low quality, with high risk of bias, and the trials were concentrated in a handful of countries: three in China, one in Russia, one in Romania, one unclear
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