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Anna Ferrulli, Department of Biomedical Sciences for Health, University of Milan, Milan 20133, Italy

PATENT CLIFF IMPACT The active ingredient, semaglutide, is the backbone of widely known drugs like Ozempic, Wegovy and Rybelsus by Danish drugmaker Novo Nordisk

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(Lausanne) 12 , 678055 (2021)

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In a 48-week phase 2 study of retatrutide involving 338 overweight or obese non-diabetic participants, researchers observed dose-dependent decreases in weight and improvements in waist circumference, blood pressure, levels of glycated hemoglobin, fasting glucose and insulin, and most lipid metrics