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Latour et al., 2015) and the brain ( Dyrk1A overexpression, induced increased phosphorylation of the serine threonine kinase Akt (on Serine 473) (Rabaneda et al., 2016) and consequently decreased phosphorylation of Akt (Liu et al., 2010, 2011

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Inflammasome activation, macrophage infiltration, and cytokine production have been documented in cystinosis, indicating that chronic inflammation plays a key role in disease pathogenesis [147]

Following 1/2 nephrectomy, these rats rapidly developed hypertension, functional decline in the remnant kidney, and marked histopathological damagehallmarks of advanced diabetic kidney disease (DKD)

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