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It directly interferes with pigment production, encouraging the skin to produce lighter pigments instead of darker ones

S.PiloneroT.SchrammH.LapierreH.et al

Cytokines and chemokines secreted by leukocytes, such as tumor necrosis factor, IL-6, and granulocyte colony-stimulating factors to name a few activate endothelial cells, stimulate neovascularization and leukocyte migration, and cause expansion of synovial fibroblast-like and macrophage-like cells [68]

Kim, K., Kim, S

This may be more common in people allergic to certain medications that resemble folic acid

Difficulty concentrating, forgetfulness, or mental sluggishness