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In clinical practice, systemic administration (orally or intravenously) of NAC is used as an antidote of paracetamol overdose

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It is not subject to feedback inhibition by glutathione (GSH) and its substrates gamma-glutamylcysteine (GGC) and glycine are rapidly ligated to form glutathione (GSH)

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Once phosphorylated the tyrosine residues of the beta subunit serve as docking sites for downstream signaling mediators including extracellular signal-regulated kinase (ERK) and the phosphatidylinositol-3-kinase (P13K) pathway [78] ( Figure 2 )

The roles of glutathione in Gram negative bacteria have been extensively reviewed [12, 13]