The slightly larger gauge means marginally more sensation on insertion, but the difference is minimal
Once you open a sterile vial, every second it sits exposed increases contamination risk
Mount Sinai Health Library
The following adverse effects were reported in patients receiving semaglutide injection or oral tablets across all clinical trials and at incidences higher than with placebo: nausea (11% to 44%), vomiting (5% to 24%), diarrhea (8.5% to 30%), abdominal pain (5.7% to 20%), abdominal distention (2% to 7%), constipation (3.1% to 24%), dyspepsia (0.6% to 9%), decreased appetite (6% to 9%), eructation (0.6% to 7%), flatulence (0.4% to 6%), gastroesophageal reflux disease (1.5% to 5%), gastroenteritis (4% to 6%), and gastritis (0.4% to 4%)
Pintaudi, B., Di Vieste, G
Every batch is independently tested and released only after passing all USP specifications so you can trust exactly what's in every vial