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Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012

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Some patients report slower response times for refill issues or clinical questions

Dessa maneira, a correta classificao dessas leses essencial para a tomada de decises clnicas , uma vez que algumas delas podem indicar condies graves que necessitam de interveno imediata

FIGURE 2 Pyruvate Kinase Activation and Red Blood Cell ATP Patients with pyruvate kinase deficiency (PKD) are susceptible to hemolytic anemia (Table 1) because RBC PK is critical for ATP generation, given the absence of mitochondria in mature RBCs