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doi: 10.1038/nm.3704 37 NakamizoSHondaTAdachiANagatakeTKunisawaJKitohAet al

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This effect of estrogen may be due to a combination of a reduction of somatostatin's inhibitory tone, amplification of endogenous GHRH levels or its pituitary actions, and activation of additional mechanisms

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Because growth hormone release is closely connected to deep sleep cycles, improving natural growth hormone signaling may help support healthier sleep patterns in some individuals

Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 19882014