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These results were more difficult to explain as the mouse plasma half-life of 11 is prolonged (31 min) and the potency (13%) is comparable to 14 (6%), 22 (19%) and 23 (7%)

Paraffin-embedded tissue was baked overnight, deparaffinized, rehydrated, and underwent heat-induced epitope retrieval using Borg Decloaker (Biocare Medical, Pacheco, CA) and a decloaking chamber (120 C for 30 sec followed by 90 C for 10 sec)

The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast