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showed that BMAL1 coordinates diurnal VEGFA expression via hypoxia-inducible factor 1 (HIF-1) in tumor models, and this mechanism also contributes to vascular repair after stroke (83)

However, individual responses vary considerably, and some patients experience persistent digestive symptoms requiring management strategies or dose adjustments

In addition, efruxifermin improved non-invasive biomarkers related to fibrosis, such as the ELF score and Pro-C3 25

If symptoms persist or worsen, we adjust treatment and evaluate for alternative causes

People with certain autoimmune conditions that may alter transport proteins (although this is rare as evidence is limited) 9