One of the most significant genetic factors associated with HT is the human leukocyte antigen - DR gene ( HLA-DR) , particularly the HLA-DR3 , DR4 , and DR5 alleles, which influence antigen presentation and immune response regulation [54, 55]
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Similarly, early-stage focal osteoarthritic lesions, where degenerative changes are limited and biomechanical alignment is preserved, can also benefit from ACI,though outcomes are generally less predictable compared to purely traumatic defects (Brittberg et al., 2016
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Research on patients using transdermal patches for neurological conditions concluded that adherence rates increased to 85.9% gradually, with patch users more likely to continue treatment than those on oral medication