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Considering a three-dimensional structural model for a complex of the human HGF-NK2 segment sandwiched by c-met receptor molecules (see supplementary Figure 3, re-produced from PDB ID 7MO7 67 , it is hypothesized that the disulfide bonds, notably Cys149-Cys189 and Cys177-Cys201 localized internally just behind Y198, are the targets of LASSS

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Santos JX, Rasga C, Marques AR, Martiniano H, Asif M, Vilela J, Oliveira G, Sousa L, Nunes A, Vicente AM (2022) A role for gene-environment interactions in autism spectrum disorder is supported by variants in genes regulating the effects of exposure to xenobiotics

It has the strongest published combination data, but its GLP-1 component is a single agonist, which means it lacks the GIP and glucagon arms that give Retatrutide its higher ceiling and its energy-expenditure edge