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The slowing of food transit through the digestive system affects the entire gastrointestinal tract, not just the stomach

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LS-mean change from baseline in HOMA-IR and TyG index showed significantly greater degree of reduction in high GLP-1 compared with low GLP-1 groups [between group difference -3.14 (95% CI -6.19, -0.100) and between group difference -0.57 (95% -1.05, -0.09) respectively]

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At just 16 amino acids long, MOTS-C peptide can traverse cellular membranes and modulate signaling networks previously thought to be governed only by nuclear-encoded factors