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Inflammation in osteoarthritis: the latest progress and ongoing challenges

2023;102(17): e33637

Chauvel, V., Multon, S

NAD+ and glutathione naturally decline with age , contributing to cellular dysfunction, oxidative stress, and increased risk of chronic diseases like Alzheimer's, Parkinson's, and metabolic disorders

Accordingly, candidate targets for charcoal rot improvement include negative regulators of immunity and genes involved in phenylpropanoid/lignin biosynthesis, pathogen perception, cell wall fortification, reactive oxygen species (ROS) homeostasis, and hormone signaling pathways (salicylic acid and jasmonic acid) that coordinate defense responses (Thomazella et al