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Added microbial therapeutic potential may exist in the expression of Hld Se in an organism like Lactobacillus reuteri , which already has inherent therapeutic properties, has Generally Recognized as Safe status, and is suitable for delivery to the gastrointestinal tract

It is also used in some weight management programs as it increases satiety, reduces appetite and helps people control their food intake

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Notably, in a previous study using a similar dose and time of administration, melatonin improved sleep in moderate to severe COPD patients, with no detrimental effects on daytime alertness, lung function, and exercise capacity [66]