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In a pooled analysis of glycemic control trials, patients reported diabetic retinopathy related adverse reactions during the trial (4.2% with semaglutide tablets and 3.8% with comparator)

Res 36 , 761765 (2004)

These include: Permeability across the intestinal wall Chemical and metabolic stability (how easily they break down) Gastrointestinal (GI) transit time Molecular size, which is often the biggest barrier To overcome these challenges, scientists have developed different strategies for improving oral delivery: Absorption enhancers These substances temporarily make the intestinal barrier more permeable or act as carriers to help peptides cross it

doi: 10.1186/s12933-018-0800-2 198 MeierJJGethmannAGtzeOGallwitzBHolstJJSchmidtWEet al

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