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What's changing in 2026: with the FDA approval of finerenone for heart failure with preserved and mildly reduced ejection fraction, the "pillars" concept is expanding into territory that previously had almost no disease-modifying options

It simultaneously suppresses glucagon secretion, slows gastric emptying, and acts centrally in the hypothalamus on satiety-regulating circuits

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Most PlexusDx patients begin noticing reduced appetite and early weight changes within 24 weeks of starting tirzepatide, though meaningful weight loss (510 pounds or more) typically emerges by week 812 as doses are titrated upward

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Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells