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In general, semaglutide (Wegovy ) and tirzepatide (Zepbound ) are FDA-approved for weight loss in people with: A BMI of 30 or higher , or A BMI of 27 or higher with at least one weight-related condition, like type 2 diabetes or high blood pressure Each medication also has additional FDA-approved uses beyond weight loss: Wegovy is also approved to reduce the risk of major cardiovascular events like heart attack and stroke in adults with cardiovascular disease

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As of June 2026, CagriSema is not FDA-approved

This venous blood then enters the heart, and following oxygenation, it reaches the liver via the hepatic artery, which accounts for 2530% of the livers blood flow [36, 37]

However, sermorelin does not directly suppress appetite, so weight loss depends primarily on concurrent lifestyle modifications