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In this comprehensive overview (see Methods and the search methodology in Supplementary Section 1), we aim to identify and describe pre-clinical, mechanistic and clinical studies on the effects of GLP-1RAs in cognitive and mental health disorders, and to provide a summary of available evidence and future perspectives

An analysis of F.D.A

The SURPASS-CVOT and retatrutide Phase 3 cardiovascular trials will generate the datasets that establish whether the dual- and triple-agonist compounds replicate the CV-outcome signal semaglutide produced, exceed it, or diverge from it

Virtual consultations may also be available for eligible patients who prefer the privacy and convenience of discussing care from home

If eligible, the provider recommends an individualized dosage and discusses lifestyle guidance to support sustainable weight loss