Currently, treatments targeting the IFN- chemokine axis, JAK-STAT pathway, and Nrf2-ARE pathway, have been recently emerged and reviewed
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Gibb FW, Homer NZM, Faqehi AMM et al (2016) Aromatase inhibition reduces insulin sensitivity in healthy men
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And then the activated Smad2 or Smad3 bind to Smad4, forming the heterogeneous Smad complex, which translocates into the nucleus and interacts with Smad-binding element (SBE) of the TGF- target gene [80]