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Abbreviations AE: Adverse event BMI: Body mass index CFR: Code of Federal Regulations CI: Confidence interval CSF: Cerebrospinal fluid EHR: Electronic health record GI: Gastrointestinal GIP: Glucosedependent insulinotropic polypeptide GLP-1: Glucagonlike peptide-1 GLP-1 RA: GLP-1 receptor agonist GRADE: Grading of Recommendations, Assessment, Development and Evaluations ICD-10: International Classification of Diseases, 10th Revision ICP: Intracranial pressure IIH: Idiopathic intracranial hypertension IQR: Interquartile range NKCC1: NaKCl cotransporter 1 OCT: Optical coherence tomography ONSF: Optic nerve sheath fenestration OR: Odds ratio PMD: Perimetric mean deviation PRISMA: Preferred Reporting Items for Systematic Reviews and MetaAnalyses RA: Receptor agonist RCT: Randomized controlled trial RNFL: Retinal nerve fiber layer ROBINS-I: Risk Of Bias In Nonrandomized Studies of Interventions RR: Risk ratio SAE: Serious adverse event SD: Standard deviation References Mollan SP, Grech O, Alimajstorovic Z et al (2020) New horizons for idiopathic intracranial hypertension: advances and challenges

provide substantial contribution to interpretation of data, critically reviewed the manuscript, contribute an important intellectual content and gave final approval of the manuscript