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Healthcare professionals may prescribe metformin alongside GLP-1 medication

The FDA based its decision on results from the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial

Participants who experienced significant nausea, vomiting, or other gastrointestinal symptoms during escalation could have their dose increase paused or delayed until symptoms resolved

Most users report short-term changes but little long-term benefit

Data were pooled using random-effects models, and subgroup analyses were performed by drug type and treatment duration

Retatrutide has never been approved, so there is no legal basis for compounding it