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Researchers have proposed that inhibiting NNMT may influence downstream metabolic pathways by altering nicotinamide utilisation and methyl donor availability

This is a class effect of GLP-1 receptor agonists

Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle

By binding two GHK molecules to each copper ion, the reactivity decreases while maintaining biological activity

Certain factors may put you at increased risk for B12 deficiencyincluding a vegetarian or vegan diet, specific medical conditions (such as Crohns or celiac disease, or a history of gastric surgery), and age over 50

Seniors are also more vulnerable as their body cant assimilate vitamin B12 well, due to a reduction in gastric acid in the intestines