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Although the overall study findings were neutral, when patients enrolled in Russia and Georgia who likely did not have HFpEF were excluded, there was a significant reduction in the primary outcome among patients in the Americas

In other words, we need a double-blind, randomized, controlled clinical trial of some magnitude

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10.1038/s41589-020-0472-6 Summary Keywords curcumin, natural medicine, neurodegenerative disease, pharmacological activity, bioavailability Citation Wang G, Zhou X, Pang X, Ma K, Li L, Song Y, Hou D and Wang X (2025) Pharmacological effects, molecular mechanisms and strategies to improve bioavailability of curcumin in the treatment of neurodegenerative diseases