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10.1111/j.1600-0773.1996.tb00228.x 20 JiangY.FanX.WangY.ChenP.ZengH.TanH.et al (2015a)

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Importantly, the majority of these experimental findings have been further corroborated in human NS workers, with clear differences compared to day workers observed across multiple biological mechanisms (including oxidative stress, immune dysfunction, inflammation, melatonin disruption, clock gene alterations, epigenetic changes, telomere attrition, and hormonal imbalances)

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CAFs secrete a higher amount of hepatocyte growth factor than the normal fibroblasts, and the secretion capacity of CAFs around HCC is positively correlated with the tumor size (Jia et al., 2013)

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