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Nat Rev Drug Discov

The study also revealed the underlying mechanism: autoantibodies and IFN- in SLE serum enhance the binding of the transcription suppressor CREM to the Gpx4 promoter, which in turn suppresses Gpx4 expression

Sikirics team looked for this protective substance directly in gastric juice, and they found it

For example, PAE not only protects against AS but also exerts neuroprotective effects by inhibiting neuronal ferroptosis in cerebral hemorrhage (Jin et al., 2021) and serves as an antidepressant (Wei et al., 2023)

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It is not studied in pregnancy