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Developed by the Russian Institute of Molecular Genetics, Semax is a synthetic heptapeptide (a chain of seven amino acids) that is essentially an analog of a naturally occurring hormone known as ACTH (Adrenocorticotropic hormone) but completely lacking the hormonal side effects

week-0 baseline

While NRF2 activates NADPH production through the upregulation of the pentose phosphate pathway, malic enzyme, and isocitrate dehydrogenase, NRF2 also supports cellular NADPH levels by suppressing NADPH-consuming processes

The most important genes and enzymes in the methylation cycle (highlighted in black)

& Rock, C

Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance