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Why Opioids Backfire With Repeated Use With repeated exposure, the nervous system adapts to opioids, leading to: Tolerance , requiring higher doses for the same effect (33,35) Dependence , with withdrawal symptoms when doses wear off (35) Opioid-induced hyperalgesia , a paradoxical increase in pain sensitivity (33,36) Rather than calming pain long term, opioids can sensitize the nervous system, making everyday stimuli feel more painful (33,36)

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Previous studies reported that SIPS can be triggered by oxidative stress caused by tBH and H 2 O 2 10,11

However, if redness, swelling, or warmth persists for more than 72 hours, or if a firm lump develops and doesnt resolve, contact your provider

Vitamin B12 is a water-soluble vitamin that supports brain and nervous system health, helps make DNA, and more

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