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Cohort 2 consisted of patients 18 to 64 years of age who received 6 or more intramuscular injections (fee codes G372 and G373) within 1 year and had a vitamin B12 level laboratory test (fee code L345) 2 months before the intramuscular injection claim

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Thus it is not surprising that compounds that increase the activity of the P450 enzymes, such as caffeine[40, 41] and anticonvulsant drugs[42] also make APAP more hepatotoxic