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[1] Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations

At approved weight-loss doses, caloric intake typically decreases in a consistent and measurable way

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Even when opening a vial, researchers should take steps to minimise exposure to open air, particularly in rooms where humidity is not strictly controlled

Data availability All data used for this paper are publicly available and are provided in the main text and Supplementary Information

Patients need a multidisciplinary team approach, including dietary counseling and frequent visits to monitor and support their success