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doi: 10.1002/rmb2.12353 2 AgarwalASenguptaP

Such effects are consistent with their established reduction in atherosclerotic cardiovascular events and may be particularly relevant in patients with obesity, insulin resistance, or HFpEF phenotypes, and taken together, these mechanistic differences provide a biologically plausible rationale for combination therapy: SGLT2 inhibitors primarily target HF-related hemodynamic and cardiorenal pathways, whereas GLP-1 receptor agonists may further improve metabolic and vascular risk

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Furthermore, advancements in delivery systems and the development of standardized formulations are crucial for enhancing the bioavailability and therapeutic effectiveness of PCs

While promising, these sprays are currently for research purposes, with ongoing studies to refine their efficacy and safety