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These larger, longer-duration studies will provide the comprehensive safety and efficacy data needed for FDA review

Oral semaglutide is not appropriate for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Caroline Apovian, codirector of the Center for Weight Management and Wellness at Brigham and Women's Hospital, also worries that the press release announcing the trial results may understate how common severe nausea and vomiting were, because it does not specify how many patients dropped out specifically because of those effects