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The key steps are: Identify the gastro-esophageal junction as at the tops of the gastric mucosal folds If hiatus hernia is present, do not mistake the diaphragmatic hiatal impression for the gastro-esophageal junction For circumferential columnar-appearing mucosa above the gastro-esophageal junction define this extent in centimetres above the gastro- esophageal junction: report as the C value For any tongue-like areas of columnar-appearing mucosa, measure the Maximum extent in centimetres above the gastro-esophageal junction: report as the M value The IWGCO has produced a DVD which presents background to the C&M Criteria, including an annotated video clip that explains the Criteria, and endoscopic video clips designed to build experience in the use of the Criteria

Its characterization is limited to physicochemical properties, molecular structure, and stability-focused investigation under non-clinical research conditions