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Thus, the interpretation of existing findings is challenging, and further research is required to better characterise bone responses to various IF schedules using well-controlled protocols of longer duration, adequately powered to assess changes in bone outcomes and designed to include clinically relevant bone assessments (BMD at the hip/lumbar spine, bone microstructure and fracture risk)

L., & Dawson, T

This is especially relevant for tirzepatide dosing , where the escalation steps are larger and side effects at each new dose can be more pronounced

S., & Hecht, S

No, the application methods are painless and comfortable

Other studies have induced depressive behavior through sleep deprivation protocols [37, 38], chronic water immersion restraint stress [39], reactivity model conjugated to social stress [40], and chronic unpredictable mild stress (CUMS) [41, 42] (Fig